R-00326-2002.R2 Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats
نویسندگان
چکیده
John W. Wright, Elizabeth Tamura-Myers, Wendy L. Wilson, Bernard P. Roques, Catherine Llorens-Cortes, Robert C. Speth, and Joseph W. Harding Departments of Psychology, Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Program in Neuroscience, Washington State University, Pullman, WA 99164-4820, Institut National de la Santé et de la Recherche Medicale, Unite 266, Department de Pharmacochimie Moleculaire et Structurale, Centre National de la Recherche Scientifique, UMR 8600, 4 Avenue de l'Observatoire, 75270, Paris, Cedex 06, France; Institut National de la Sante de la Recherche Medicale, Unit 36, College de France, Chaire de Medecine Experimentale, 11 Place Marcellin Berthelot, 75005 Paris France.
منابع مشابه
Central pressor actions of aminopeptidase-resistant angiotensin II analogs: challenging the angiotensin III hypothesis.
UNLABELLED Intracerebroventricular administration of angiotensins causes pronounced pressor and dipsogenic responses. The suggestion that angiotensin III rather than angiotensin II is the active peptide in the brain spawned what we call The Angiotensin III. HYPOTHESIS To test this hypothesis, 5 angiotensin II analogs containing zero or one position substitutions conferring resistance to amino...
متن کاملEffects of an orally active converting-enzyme inhibitor, SQ 14225, on pressor responses to angiotensin administered into the brain ventricles of spontaneously hypertensive rats.
1. Two hours after oral feeding of normotensive Wistar Kyoto rats with the converting-enzyme inhibitor SQ 14225 (1 and 10 mg/kg), an increase of angiotensin I plasma concentrations from 892 +/- 113 to 1660 +/- 167 and 2951 +/- 405 pg/ml was observed. 2. Administration of SQ 14225 with the drinking fluid overnight suppressed the pressor responses to intravenous angiotensin I, although the blood ...
متن کاملConversion of brain angiotensin II to angiotensin III is critical for pressor response in rats.
The present investigation measured the relative pressor potencies of intracerebroventricularly infused ANG II, ANG III, and the metabolically resistant analogs d-Asp(1)ANG II and d-Arg(1)ANG III in alert freely moving rats. The stability of these analogs was further facilitated by pretreatment with the specific aminopeptidase A inhibitor EC33 or the aminopeptidase N inhibitor PC18. The results ...
متن کاملConversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats.
In the kidney, angiotensin II (Ang II) is metabolized to angiotensin III (Ang III) by aminopeptidase A (APA). In turn, Ang III is metabolized to angiotensin IV by aminopeptidase N (APN). Renal interstitial (RI) infusion of Ang III, but not Ang II, results in angiotensin type-2 receptor (AT(2)R)-mediated natriuresis. This response is augmented by coinfusion of PC-18, a specific inhibitor of APN....
متن کاملBlockade of Central Angiotensin II AT1 Receptor Protects the Brain from Ischemia/Reperfusion Injury in Normotensive Rats
Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting reports about the effects of Angiotensin II on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. In this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin II AT1 receptor b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2002